Appomattox Court House, the final surrender of Confederate General Robert E. Lee to Union General Ulysses S. Grant. Lee was attempting to retreat from Richmond to regroup with forces from the Carolinas, but was pressed hard by Grant and eventually surrounded with no source of supply. Minor resistance continued, but this is generally considered the end of the Confederacy. The Civil War cost some 620,000 lives.
Then 421 miles to Home Sweet Home.